| Match date | Home / Away | Opponent | Competition | Score | PL Points | |
| July 2016 | ||||||
| 26 Tue | Melbourne | Juventus | International Champions Cup | 1-2 | ||
| 29 Fri | Melbourne | Atletico Madrid | International Champions Cup | 0-1 | ||
| August 2016 | ||||||
| 05 Fri | Oslo | Inter Milan | 6-1 | |||
| 13 Sat | Away | Everton | Barclays Premier League | Matchday 1 | 1-1 | 1 |
| 20 Sat | Home | Crystal Palace | Barclays Premier League | Matchday 2 | 1-0 | 4 |
| 27 Sat | Home | Liverpool | Barclays Premier League | Matchday 3 | 1-1 | 5 |
| September 2016 | ||||||
| 10 Sat | Away | Stoke City | Barclays Premier League | Matchday 4 | 0-4 | 8 |
| 14 Wed | Wembley | Monaco | Champions League | Matchday 1 | 1-2 | |
| 18 Sun | Home | Sunderland | Barclays Premier League | Matchday 5 | 1-0 | 11 |
| 21 Wed | Home | Gillingham | Capital One Cup | 3rd Round | 5-0 | |
| 24 Sat | Away | Middlesbrough | Barclays Premier League | Matchday 6 | 1-2 | 14 |
| 27 Tue | Away | CSKA Moscow | Champions League | Matchday 2 | 0-1 | |
| October 2016 | ||||||
| 02 Sun | Home | Manchester City | Barclays Premier League | Matchday 7 | 2-0 | 17 |
| 15 Sat | Away | West Bromwich Albion | Barclays Premier League | Matchday 8 | 1-1 | 18 |
| 18 Tue | Away | Bayer Leverkusen | Champions League | Matchday 3 | 0-0 | |
| 22 Sat | Away | AFC Bournemouth | Barclays Premier League | Matchday 9 | 0-0 | 19 |
| 25 Tue | Away | Liverpool | Capital One Cup | 4th Round | 1-2 | |
| 29 Sat | Home | Leicester City | Barclays Premier League | Matchday 10 | 1-1 | 20 |
| November 2016 | ||||||
| 02 Wed | Wembley | Bayer Leverkusen | Champions League | Matchday 4 | 0-1 | |
| 06 Sun | Away | Arsenal | Barclays Premier League | Matchday 11 | 1-1 | 21 |
| 19 Sat | Home | West Ham United | Barclays Premier League | Matchday 12 | 3-2 | 24 |
| 22 Tue | Away | Monaco | Champions League | Matchday 5 | 2-1 | |
| 26 Sat | Away | Chelsea | Barclays Premier League | Matchday 13 | 2-1 | 24 |
| December 2016 | ||||||
| 03 Sat | Home | Swansea City | Barclays Premier League | Matchday 14 | 5-0 | 27 |
| 07 Wed | Wembley | CSKA Moscow | Champions League | Matchday 6 | 3-1 | |
| 11 Sun | Away | Manchester United | Barclays Premier League | Matchday 15 | 1-0 | 27 |
| 14 Wed | Home | Hull City | Barclays Premier League | Matchday 16 | 3-0 | 30 |
| 18 Sun | Home | Burnley | Barclays Premier League | Matchday 17 | 2-1 | 33 |
| 28 Wed | Away | Southampton | Barclays Premier League | Matchday 18 | 1-4 | 36 |
| January 2017 | ||||||
| 01 Sun | Away | Watford | Barclays Premier League | Matchday 19 | 1-4 | 39 |
| 04 Wed | Home | Chelsea | Barclays Premier League | Matchday 20 | 2-0 | 42 |
| 08 Sun | Home | Aston Villa | FA Cup | 3rd round | 2-0 | |
| 14 Sat | Home | West Bromwich Albion | Barclays Premier League | Matchday 21 | 4-0 | 45 |
| 21 Sat | Away | Manchester City | Barclays Premier League | Matchday 22 | 2-2 | 46 |
| 28 Sat | Home | Wycombe Wanderers | FA Cup | 4th round | 4-3 | |
| 31 Tue | Away | Sunderland | Barclays Premier League | Matchday 23 | 0-0 | 47 |
| February 2017 | ||||||
| 04 Sat | Home | Middlesbrough | Barclays Premier League | Matchday 24 | 1-0 | 50 |
| 11 Sat | Away | Liverpool | Barclays Premier League | Matchday 25 | 2-0 | 50 |
| 16 Thu | Away | Gent | 2nd round Europa League, 1st leg | 1-0 | ||
| 19 Sun | Away | Fulham | FA Cup | 5th round | 3-0 | |
| 23 Thu | Home | Gent | 2nd round Europa League, 2nd leg | 2-2 | ||
| 26 Sun | Home | Stoke City | Barclays Premier League | Matchday 26 | 4-0 | 53 |
| March 2017 | ||||||
| 05 Sun | Home | Everton | Barclays Premier League | Matchday 27 | 3-2 | 56 |
| 12 Sun | Home | Millwall | FA Cup | Qtr. Final | 6-0 | |
| 19 Sun | Home | Southampton | Barclays Premier League | Matchday 28 | 2-1 | 59 |
| April 2017 | ||||||
| 01 Sat | Away | Burnley | Barclays Premier League | Matchday 29 | 0-2 | 62 |
| 05 Wed | Away | Swansea City | Barclays Premier League | Matchday 30 | 1-3 | 65 |
| 08 Sat | Home | Watford | Barclays Premier League | Matchday 31 | 4-0 | 68 |
| 15 Sat | Home | AFC Bournemouth | Barclays Premier League | Matchday 32 | 4-0 | 71 |
| 22 Sat | Wembley | Chelsea | FA Cup | Semi Final | 2-4 | |
| 26 Wed | Away | Crystal Palace | Barclays Premier League | Matchday 33 | 0-1 | 74 |
| 30 Sun | Home | Arsenal | Barclays Premier League | Matchday 34 | 2-0 | 77 |
| May 2017 | ||||||
| 05 Fri | Away | West Ham United | Barclays Premier League | Matchday 35 | 1-0 | 77 |
| 14 Sun | Home | Manchester United | Barclays Premier League | Matchday 36 | 2-1 | 80 |
| 18 Thu | Away | Leicester City | Barclays Premier League | Matchday 37 | 1-6 | 83 |
| 21 Sun | Away | Hull City | Barclays Premier League | Matchday 38 | 1-7 | 86 |